Figure 6.

The rs7132908 obesity risk allele dramatically decreases the proportion of neurons produced by hypothalamic neuron differentiation

(A) Representative brightfield images of hypothalamic neurons mid-differentiation on day 29 (scale bar, 100 μm). Cells were homozygous for either the rs7132908 non-risk allele (left) or obesity risk allele (right).

(B and C) Proportion of total cells homozygous for the rs7132908 non-risk allele annotated as each cell type (n = 4 differentiation replicates) (B) and homozygous for the rs7132908 obesity risk allele annotated as each cell type (n = 4 differentiation replicates) (C). Data are represented as mean ± SD. See also Figure S3.