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Mediation analyses with MoCA as cognitive outcome. In this study, the relationship between OH and cognitive impairment was mediated by A, Aβ42; B, T-tau; C, P-T181-tau; D, C3b; and E, C5b-9; but F, CD55 cannot mediate the association between OH and cognition. Aβ42, amyloid beta42; DE, direct effect; IE, indirect effect; MoCA, Montreal Cognitive Assessment; OH, orthostatic hypotension; P-T181-tau, tau phosphorylated at threonine 181; T-tau, total tau.
