TABLE 3.
BLCM including information on posterior median and 95% credible interval values for conditional dependent BLCMs for the prevalence of sepsis in calves and the sensitivity and specificity for sepsis diagnosis with hypoglycemia (<60 mg/dL) and positive aerobic plus and peds plus blood culture vials.
| Model 1: no priors a | Model 2: se/sp hypoglycemia | Model 3: sepsis prevalence + se/sp hypoglycemia | ||||
|---|---|---|---|---|---|---|
| Test | Prior density | Posterior density (median % [95% CI]) | Prior density | Posterior density (median % [95% CI]) | Prior density | Posterior density (median % [95% CI]) |
| Hypoglycemia | ||||||
| Sensitivity | Beta (1,1) | 54.4 (12.6‐94.6) | Beta (34.44, 23.29) | 58.7 (46.7‐70.5) | Beta (34.44, 23.29) | 58.6 (46.8‐70.3) |
| Specificity | Beta (1,1) | 75.8 (27.1‐94.5) | Beta (47.53, 20.94) | 72.9 (64.9‐80.3) | Beta (47.53, 20.94) | 73.0 (65.0‐80.3) |
| Pediatric plus | ||||||
| Sensitivity | Beta (1,1) | 57.6 (9.5‐95.9) | Beta (1,1) | 68.9 (30.0‐97.9) | Beta (1,1) | 68.7 (30.8‐97.7) |
| Specificity | Beta (1,1) | 85.2 (33.7‐98.4) | Beta (1,1) | 87.3 (72.1‐98.3) | Beta (1,1) | 87.6 (72.4‐98.4) |
| Aerobic plus | ||||||
| Sensitivity | Beta (1,1) | 71.0 (15.1‐98.3) | Beta (1,1) | 80.3 (40.6‐98.9) | Beta (1,1) | 80.2 (42.2‐98.9) |
| Specificity | Beta (1,1) | 77.1 (22.1‐97.0) | Beta (1,1) | 78.6 (63.2‐95.5) | Beta (1,1) | 78.9 (63.6‐95.7) |
| Prevalence | Beta (1,1) | 28.0 (4.7‐88.3) | Beta (1,1) | 23.4 (4.8‐44.3) | Beta (1.16, 1.38) | 23.9 (5.9‐44.2) |
| covDp | U (0, a) | 0.05 (−0.08 to 0.17) | U (0, a) | 0.02 (−0.06 to 0.17) | U (0, a) | 0.02 (−0.06 to 0.17) |
| covDn | U (0, b) | 0.04 (−0.02 to 0.15) | U (0, b) | 0.04 (−0.008 to 0.13) | U (0, b) | 0.04 (−0.008 to 0.12) |
| DIC | 32.6 | 36.9 | 36.9 | |||
Abbreviations: CI, credibility interval; covDn, covariance for negatives; covDp, covariance for positives; DIC, deviance information criterion; Se, sensitivity; Sp, specificity.
a
Model did not converge.