TABLE 2.

Descriptive statistics on clinicopathological variables at enrolment for CKD cats in this prospective imaging study, grouped according to the ionized calcium status (“CKD normocalcemia” vs “CKD hypercalcemia”).

Variables (reference interval)	CKD normocalcemia (n = 20)		CKD hypercalcemia (n = 16)		P‐value
	Median [25th, 75th percentile]	n	Median [25th, 75th percentile]	n
Total calcium (8.2‐11.8 mg/dL)	9.86 [9.75, 10.09]	20	10.9 [10.5, 11.66]	16	<.001
Ionized calcium (4.76‐5.48 mg/dL)	5.28 [5.23, 5.37]	20	5.7 [5.67, 6.19]	16	<.001
Age (years)	14.6 [13.2, 16.6]	20	14.5 [12.6, 16.7]	16	.73
BCS (“1‐3,” “4‐6,” “7‐9,” n [%])	9 [45], 11 [55], 0 [0]	20	3 [19], 12 [75], 1 [6]	16	.16
MCS (“0,” “1,” “2,” “3,” n [%])	1 [5], 6 [30], 13 [66], 0 [0]	20	2 [13], 1 [7], 11 [73], 1[7]	15	.21
Weight (kg)	3.4 [3.1, 4.2]	20	3.8 [3.2, 4.6]	16	.24
Sex (female neutered, n [%])	9 [45]	20	9 [56]	16	.5
Albumin (2.5‐4.5 g/dL)	2.9 [2.8, 3.1]	20	3.2 [3.1, 3.3]	16	.01
ALP (≤ 60 U/L)	29 [20, 34]	20	23 [20, 25]	16	.19
ALT (5‐60 U/L)	50 [38, 60]	20	49 [37, 59]	16	.82
CaPP (<70 mg2/dL2)	38.3 [33.9, 45.5]	20	42.8 [37.4, 51.7]	16	.09
Chloride (100‐124 mEq/L)	119 [115, 120]	9	119 [117126]	6	.20
Creatinine (0.23‐2 mg/dL)	2.53 [2.18, 3.07]	20	2.24 [2.00, 2.83]	16	.29
FGF23 a (56‐700 pg/mL)	391 [265, 852]	18	756 [326, 1983]	15	.22
Glucose (54‐117 mg/dL)	106 [93, 130]	20	114 [106, 129]	16	.31
Venous HCO3 − (17‐24 mEq/L)	22.5 [19.7, 23.6]	20	21.0 [8.5, 22.0]	16	.1
Hypertension (controlled) (n [%])	2 [10]	20	2 [12.5]	16	1
PCV (30‐45%)	34 [28, 37]	20	32 [30, 34]	16	.57
Venous pH (7.21‐7.44)	7.38 [7.35, 7.4]	20	7.37 [7.29, 7.37]	16	.07
Phosphate (2.79‐6.81 mg/dL)	3.90 [3.42, 4.38]	20	3.75 [3.53, 4.35]	16	.96
Potassium (3.5‐5.5 mEq/L)	3.9 [3.4, 4.1]	20	3.7 [3.5, 4.0]	16	.63
PTH a (2.6‐17.6 pg/mL)	20.9 [8.9, 55.4]	17	5.1 [0.6, 13.3]	14	.003
SBP (<160 mm Hg)	128 [120, 143]	20	124 [121, 133]	16	.38
SDMA (1‐14 μg/dL)	19 [17, 25]	20	17 [14, 24]	16	.41
Sodium (145‐157 mEq/L)	152 [150, 152]	20	151 [149, 151]	16	.52
Total magnesium (1.73‐2.57 mg/dL)	2.05 [1.91, 2.19]	20	2.01 [1.79, 2.24]	16	.44
Total protein (6.0‐8.0 g/dL)	7.9 [7.3, 8.5]	20	7.5 [7.2, 8.0]	16	.52
Urea (7.0‐27.7 mg/dL)	47.3 [42.9 51.5]	9	44.3 [36.6, 50.7]	6	.6
USG (≥1.035)	1.016 [1.015, 1.017]	14	1.017 [1.015, 1.022]	9	.42
Urine pH	6.0 [5.0, 6.8]	14	6.0 [5.0, 6.0]	9	.66
Nephrocalcinosis (“Y,” n [%])	9 [45]	20	13 [81]	16	.04
Of which suspected	3 [30]	9	7 [54]	13	.42

Note: Significant difference between groups (P ≤ .05) are highlighted in bold.

Abbreviations: ALP, alkaline phosphatase; ALT, alanine aminotransferase; BCS, body condition score; CaPP, calcium phosphate product; FGF23, fibroblast growth factor‐23; HCO₃ ⁻, bicarbonate; MCS, muscle condition score; n, number of cats; PCV, packed cell volume; PTH, parathyroid hormone; SBP, systolic blood pressure; SDMA, symmetric dimethylarginine; USG, urine specific gravity.

^a Baseline FGF23 and PTH were log‐transformed for comparison using independent samples t‐test and Mann‐Whitney U test, respectively.