TABLE 6.
Linear mixed model and generalized linear mixed model analyses examining the change in clinicopathological variables over time in all enrolled CKD cats (n = 36) during the study period.
| Variables | Group | Time | Group*Time |
|---|---|---|---|
| BCS (“1‐3,” “4‐9”) | .77 | .06 | .39 |
| MCS (“0,” “1,” “2,” “3”) | .79 | .06 | .41 |
| Body weight (kg) | .37 | .003 | .16 |
| Albumin (g/dL) | .04 | .25 | .06 |
| ALP (U/L) | .93 | .21 | .23 |
| ALT (U/L) | .02 | .32 | .52 |
| Creatinine (0.23‐2 mg/dL) | .14 | .03 | .83 |
| ln[FGF23] (pg/mL) | .12 | .72 | .04 |
| Venous HCO3 − (mEq/L) | .5 | .81 | .6 |
| Ionized calcium (mg/dL) | .11 | .13 | .79 |
| PCV (%) | .19 | .14 | .13 |
| Venous pH | .43 | .22 | .54 |
| Phosphate (mg/dL) | .12 | <.001 | .41 |
| Potassium (mEq/L) | .11 | .98 | .11 |
| ln[PTH] (pg/mL) | .62 | .61 | .05 |
| SBP (mm Hg) | .41 | .4 | .46 |
| SDMA (μg/dL) | .22 | .22 | .72 |
| Sodium (mEq/L) | .07 | .33 | .16 |
| Total calcium (mg/dL) | .03 | .15 | .38 |
| Total magnesium (mg/dL) | .21 | .17 | .46 |
| Total protein (g/dL) | .1 | .69 | .95 |
Note: Summary of P‐values for all variables included in the model. Group represents cats in “absence of nephrocalcinosis” or “presence of nephrocalcinosis” group based on the ultrasonographic findings at enrolment. Outcome variables showing significant change over time and between groups (P ≤ .05) are highlighted in bold. The unit used for time was month (30.4 days). A significant effect in the group column indicates a significant difference between the two groups at baseline for a given parameter (the start of the regression line at time 0). A significant effect of Group*Time interaction indicates that the rate of change of the outcome variable differs significantly between groups (“absence of nephrocalcinosis” vs “presence of nephrocalcinosis”) over time. If Group*Time was not significant, and the effect of Time was significant, this indicates no difference in the rate of change of the outcome variable between groups, however, the overall gradient of the outcome variable plotted against time (with the data from all groups combined) differs significantly from zero.
Abbreviations: ALP, alkaline phosphatase; ALT, alanine aminotransferase; BCS, body condition score; HCO3 −, bicarbonate; ln[FGF23], log‐transformed fibroblast growth factor‐23; ln[PTH], log‐transformed parathyroid hormone; MCS, muscle condition score; PCV, packed cell volume; SBP, systolic blood pressure; SDMA, symmetric dimethylarginine.