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. 2024 May 3;15:1389968. doi: 10.3389/fphar.2024.1389968

TABLE 3.

Biochemical parameters in follow-up according to sex, biogeographical origin and UGT1A1 phenotype.

N BILT (mg/dL) HGB (gr/dL) URI (mg/dL) CREA (mg/dL) GOT (U/L) GPT (U/L) ALP (U/L) GGT (U/L)
Sex
Men 414 0.72 (0.35) 15.10 (1.02) 5.38 (1.01) 0.90 (0.12) 21.95 (9.42) 20.78 (10.77) 70.94 (19.39) 19.47 (13.66)
Women 359 0.58 (0.28)* 12.86 (1.01)* 3.95 (0.91)* 0.70 (0.11)* 18.68 (6.75)* 15.04 (6.40)* 63.76 (18.76)* 14.63 (8.50)*
Biogeographical origin
European 434 0.65 (0.32) 14.15 (1.47) 4.81 (1.22) 0.82 (0.15) 20.24 (8.24) 17.67 (8.07) 63.44 (18.23) 15.07 (9.88)
Latin-American 330 0.65 (0.34) 13.94 (1.56) 4.58 (1.15)*1 0.79 (0.16)*1 20.36 (8.27) 18.51 (10.88) 73.06 (19.54)*1 20.04 (13.52)*1
Other# 9 0.63 (0.36) 14.26 (1.53) 5.29 (1.50) 0.87 (0.20) 32.22 (15.01)*2 24.78 (12.56) 68.44 (23.28) 17.22 (6.16)
UGT1A1 phenotype
NM 357 0.56 (0.23) 14.14 (1.56) 4.88 (1.23) 0.81 (0.15) 20.39 (8.56) 18.04 (9.21) 66.64 (20.15) 17.62 (13.62)
IM 318 0.64 (0.27)*3 14.09 (1.47) 4.65 (1.12) 0.81 (0.16) 20.63 (7.94) 18.30 (8.24) 68.64 (18.47) 16.98 (10.58)
PM 98 1.03 (0.49)*3 13.64 (1.42)*4 4.32 (1.20)*5 0.79 (0.14) 19.95 (9.58) 17.73 (13.32) 67.74 (19.78) 16.54 (7.68)

Data are shown as mean (standard deviation) although these are non-parametric tests following the central limit theorem. BILT: total bilirubin. HGB: hemoglobin. URI: uric acid. CREA: creatinine. GOT: glutamic oxaloacetic transaminase. GPT: glutamic pyruvic transaminase. ALP: alkaline phosphatase. GGT: gamma glutamyl transpeptidase. # Other: American, Near Eastern, East Asian and Sub-Saharan African.* univariate p-value (p uv) < 0.05 compared to men. *1 p uv<0.05 compared to European. *2 p uv<0.05 compared to European and p uv<0.05 compared to Latin-American. *3 p uv<0.05 compared to NM. *4 p uv<0.05 compared to NM, and IM. *5 p uv<0.05 compared to NM.,

p uv<0.05 compared to NM., underlined: multivariate p-value (p mv) < 0.5.