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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: Lancet HIV. 2023 Aug 4;10(9):e606–e616. doi: 10.1016/S2352-3018(23)00141-8

Table 3:

Summary of In vitro developmental toxicology studies with DTG

Culture model, study DTG dosage (μM)* N Results
Murine P19C5 pluripotent stem cells and human embryonic stem cells H944 0·25, 0·5, 1, 2, 4 46–48 aggregates per condition for morphogenesis DTG was associated with impaired stem cell morphogenesis and changes to developmental regulator genes in a dose-dependent manner in both P19C5 and H9 cells.
CA1S human embryonic stem cells45 8·32 5 replicates DTG was associated with reduced expression of pluripotency markers in CA1S cells.
H9 human embryonic stem cells45 8·32 6 replicates DTG was associated with increased rates of apoptosis in H9 cells.
Sprague Dawley GD9 embryo culture42 12·6 16 embryos DTG did not affect embryo lethality, visceral yolk sac, somite number, or embryo size.
22·2 16 embryos
Zebrafish embryo culture49 100 2–4 experimental replicates DTG was associated with developmental toxicity post-fertilization.
*

Cmax for DTG in non-pregnant adults is reported as 701–1156 μM.103