Table 3.

Cross-Sectional Associations between the NLR and CSF Outcomes in the Amyloid Positive and Amyloid Negative Subsets of the ADNI and NYU Cohorts

ADNI Cohort	Aβ Negative (n = 73)				Aβ Positive (n = 38)
	Univariate Model		Adjusted Model		Univariate Model		Adjusted Model
CSF Outcome	β ± SE	p-value	β ± SE	p-value	β ± SE	p-value	β ± SE	p-value
Aβ42	0.312 ± 3.749	0.934	-3.057 ± 3.934	0.440	-2.640 ± 4.465	0.558	2.145 ± 5.173	0.682
t-tau	5.848 ± 3.221	0.074	5.620 ± 3.548	0.118	-1.473 ± 6.596	0.825	-7.596 ± 8.355	0.371
p-tau	-0.237 ± 1.471	0.872	0.197 ± 1.614	0.903	2.483 ± 4.735	0.603	-0.204 ± 6.250	0.974
NYU Cohort	Aβ Negative (n = 152)				Aβ Positive (n = 38)
	Univariate Model		Adjusted Model		Univariate Model		Adjusted Model
CSF Outcome	β ± SE	p-value	β ± SE	p-value	β ± SE	p-value	β ± SE	p-value
Aβ42	12.538 ± 16.199	0.440	3.946 ± 16.398	0.810	9.641 ± 18.712	0.610	17.645 ± 24.974	0.486
t-tau	21.980 ± 10.619	0.040	12.015 ± 10.371	0.249	171.399 ± 38.922	< 0.001	100.476 ± 45.914	0.037
p-tau	3.279 ± 1.364	0.017	2.453 ± 1.406	0.083	15.105 ± 4.435	0.002	8.037 ± 5.256	0.138

Unadjusted and adjusted linear regression models for the association of the NLR and the three outcome variables are shown (Aβ42, t-tau, p-tau). Adjusted models included age, sex, education, race, APOE4, time between CBC and CSF exams, BMI, history of hypertension, and diabetes. Aβ positivity was defined by the CSF cut-off threshold for each cohort. β coefficients, standard errors, and p-values are shown