Table 1.
Baseline and Clinical Characteristics of the Study Population
| Patients Characteristics | Sepsis (n = 50) | ARDS (n = 118) | χ2/Z/t | P |
|---|---|---|---|---|
| Sex [male, n (%)] | 24 (48.00) | 74 (62.71) | 3.127 | 0.077 |
| Age, years, mean ± SD | 69.28 ± 9.39 | 71.01 ± 8.69 | −1.151 | 0.327 |
| Infection sites leading to ICU admission, n(%) | 3.307 | 0.508 | ||
| Respiratory infection | 20 (40.00) | 65 (55.08) | 3.197 | 0.074 |
| Urinary tract infection | 7 (14.00) | 12 (10.17) | 0.514 | 0.474 |
| Bloodstream infections | 6 (12.00) | 10 (8.47) | 0.180 | 0.674 |
| Abdominal cavity infection | 12 (24.00) | 23 (19.49) | 0.433 | 0.511 |
| Others | 5 (10.00) | 8 (6.78) | 0.159 | 0.690 |
| Past medical history, n (%) | 3.042 | 0.385 | ||
| Coronary heart disease | 16 (32.00) | 35 (29.66) | 0.091 | 0.763 |
| Hypertension | 26 (52.00) | 80 (67.80) | 3.763 | 0.052 |
| Diabetes mellitus | 29 (58.00) | 56 (47.46) | 1.561 | 0.211 |
| Cerebrovascular disease | 20 (40.00) | 36 (30.51) | 1.424 | 0.233 |
| Laboratory indicators | ||||
| WBC, x 109/L, mean ± SD | 15.18 ± 7.25 | 13.38 ± 6.06 | 1.655 | 0.100 |
| Neutrophil, x 109/L, mean ± SD | 12.94 ± 6.40 | 11.06 ± 6.30 | 1.762 | 0.080 |
| CRP, mg/L, mean ± SD | 132.24 ± 82.31 | 118.04 ± 80.05 | 1.043 | 0.299 |
| PCT, ng/mL, median (IQR) | 12.60 (2.38,24.68) | 23.36 (8.34, 44.77) | −2.545 | 0.011 |
| IL-6, pg/mL, median (IQR) | 129.41 (42.05, 1888.24) | 1827.28 (210.70, 9904.21) | −3.556 | 0.000 |
| Platelet, x109 /L, mean ± SD | 163.56 ± 104.94 | 160.88 ± 90.40 | −0.034 | 0.515 |
| Albumin, g/L, mean ± SD | 30.93 ± 5.24 | 30.06 ± 4.71 | 0.511 | 0.977 |
| Creatinine, umol/L, median (IQR) | 157.95 (94.80, 231.43) | 123.95 (77.08, 227.73) | −1.431 | 0.152 |
| Bun, mmol/L, median (IQR) | 14.03 (10.29, 20.30) | 13.48 (7.31, 23.25) | −1.003 | 0.316 |
| APACHE II score, median (IQR) | 21.00 (17.00, 26.00) | 27.00 (19.00,32.00) | −3.755 | 0.000 |
| SOFA score on day 1, median (IQR) | 7.00 (5.00, 10.00) | 11.00 (8.00, 15.00) | −5.193 | 0.000 |
| Calcium, mmol/L, median (IQR) | 1.14 (1.06, 1.26) | 1.15 (1.07,1.23) | −0.049 | 0.961 |
| Sodium, mmol/L, mean ± SD | 140.83 ± 6.86 | 138.88 ± 8.73 | 0.886 | 0.435 |
| Mrp 8/14, ug/mL, median (IQR) | 3.94 (2.06, 10.77) | 15.61 (9.67,24.34) | −6.697 | 0.000 |
Notes: P value below 0.05 indicate statistical significance.
Abbreviations: APACHE II score, Acute physiology and chronic health evaluation II score; WBC, White blood cell; CRP, C-reactive protein; PCT, Procalcitonin; SOFA score, Sequential Organ Failure Assessment score; IL-6, Interleukin-6; Bun, Blood urea nitrogen; Mrp 8/14, Myeloid-related proteins 8 and 14; ICU, Intensive care unit; IQR, Inter quartile range; SD, Standard deviation.