Table 1.
Stiffness and stress relaxation measured in previous studies using hydrazone-crosslinked hydrogels of various crosslinker architectures.
| Crosslinking architecture | Materials (MW, kDa) | Total polymer (wt%) | Elastic modulus (kPa) | Stress relaxation τ1/2 (see) | Literature |
|---|---|---|---|---|---|
| Side-chain | ELP-HYD-RGD (37) HA-ALD or BLD (100) |
2 | 2.2 ~ 2.5 | 1,529 ~ 8,701 | Roth, J. & Huang M. 2023 |
| Side-chain | HA-hydrazide (85) HA-aldehyde (96) |
3 | 4.6 | 700 | A. N. Borelli, Adv. Healthc. Mater. 2022 |
| Side-chain | HA-HYD (39/75) HA-ALD (39/75) |
2 | 0.7 ~ 5.1 | 1,217 ~ 3,558 | J. Lou, Adv. Mater. 2021 |
| Side-chain | ELP-HYD-RGD (37) HA-ALD or BLD (100) |
2 | 1.1 ~ 2.64 | 1,507 ~ 64,800 | D. R. Hunt, Adv. Sci. 2021 |
| Side-chain | HA-HYD (20/120); COL HA-ALD or BLD (20/120) |
1 ~ 2.25 | 0.01 ~ 0.5 | *233~18,000 | J. Lou, Biomaterials, 2018 |
| Linear | PLGA-HYD (150) PEG-2ALD (4) |
5 ~ 11 | 1.5 ~ 6.4 | - | S. Li, ACS Biomater. Sci. Eng. 2023 |
| Linear | Adipic dihydrazide Oxidized alginate (114) |
2 | 0.7 | 302 | F. L. C. Morgan, Adv. Healthc. Mater. 2022 |
| Linear | Adipic dihydrazide Oxidized alginate (69.6) |
2 | 0.1 | 4,100 | F. A. A. Ruiter, Adv. Sci. 2022 |
| Linear | Alginate-HYD (420) PEG-2BLD (2) |
3 ~ 10 | 30 ~ 300 | - | L. Qiao, J. Mater. Sci. 2019 |
| Star | 8-arm PEG-HYD (20) Oxidized Xanthan |
3 ~ 5 | 0.2 ~ 0.8 | - | P. K. Sharma, ACS Appl. Mater. Interfaces 2018 |
| Star-star | 8-arm PEG-HYD (10); COL 8-arm PEG-ALD or BLD (10) |
2.75 | 0.4 | *187 ~ 21,000 | S. Sinha, Adv. Healthc. Mater. 2023 |
| Star-star | 8-arm PEG-HYD (10) 8-arm PEG-ALD or BLD (10) |
3 | 15.2 | 4, 262~ 9,789 | B. M. Richardson, Adv. Healthc. Mater. 2021 |
| Star-star | 8-arm PEG-HYD (20) 8-arm PEG-ALD (20) |
5 ~ 10 | 1.6 | - | P. K. Sharma, Biomacromolecules 2019 |
| Star-star | 8-arm PEG-HYD (20) 8-arm PEG-ALD or BLD (20) |
5 | 58 | 1,980 ~ 14,904 | B. M. Richardson, Acta Biomater. 2019 |
| Star-star | 8-arm PEG-HYD (10) 8-arm PEG-ALD (10) |
120 | 31.9 | 85 | D. D. McKinnon, Soft Matter 2014 |
| Star-star | 8-arm PEG-HYD (10) 4-arm PEG-HYD (20) 4-arm PEG-ALD (10) 4-arm PEG-ALD (10) |
36 | 1.7 ~ 26.1 | 19 ~ 47 | D. D. McKinnon, Adv. Mater. 2014 |