Table 2.

Gene-Drug Pairs Included in Pharmacogenetic Testing

Gene	Associated Drug(s)	Variant/Star Allele(s) Included
CYP2C19	Citalopram, Clopidogrel, Doxepin, Escitalopram, Lansoprazole, Omeprazole, Pantoprazole, Voriconazole	*2, *3, *4.001, *4.002, *5, *6, *7, *8, *9, *10, *17, *35
CYP2D6	Amitriptyline, Atomoxetine, Clomipramine, Codeine, Desipramine, Doxepin, Imipramine, Fluvoxamine, Nortriptyline, Paroxetine, Tamoxifen, Tramadol, Trimipramine	*2 ,*3, *4.013, *4, *5, *6, *7, *8, *9, *10, *12, *13, *14, *15, *17, *21, *29, *31, *36, *40, *41, *42, *49, *56, *59, *68, copy number variants, tandem and hybrid variants
CYP3A5	Tacrolimus	*3, *6, *7
CYP2C9	Celecoxib, Flurbiprofen, Fosphenytoin, Ibuprofen, Meloxicam, Phenytoin, Piroxicam, Warfarin	*2, *3, *5, *6, *8, *11, *12, *13, *14, *15
VKORC1	Warfarin	c.-1639G>A (rs9923231)
CYP4F2	Warfarin	*3
DPYD	Capecitabine, Fluorouracil	c.[1236G>A;1129–5923C>G] (rs56038477; rs75017182), c.1679T>G (rs55886062), c.1905+1G>A (rs3918290), c2846A>T (rs67376798), c.557A>G (rs115232898)
HLA-B (*57:01 proxy: HCP5)	Abacavir	n.852T>G (rs2395029)
SLCO1B1	Simvastatin, Atorvastatin, Rosuvastatin	*5
TPMT	Azathioprine, Mercaptopurine, Thioguanine	*2, *3A, *3B, *3C, *4