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. Author manuscript; available in PMC: 2024 May 17.
Published in final edited form as: J Med Chem. 2023 Jan 20;66(3):1809–1834. doi: 10.1021/acs.jmedchem.2c01624

Figure 4. Dose-dependent effects of cariprazine on cocaine self-administration in rats.

Figure 4.

(A) The dose-dependent effects of cariprazine on cocaine self-administration (infusions). (B) Effects of cariprazine on inactive lever presses. (C) Representative cocaine self-administration (infusions) records, illustrating the typical extinction-like patterns of drug taking and drug seeking—lower doses of cariprazine (0.3 mg/kg) increased, while at higher doses it produced an initial burst-like drug infusions followed by cessation of drug self-administration. *p < 0.05, **p < 0.01, compared to vehicle (0 mg/kg).