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. Author manuscript; available in PMC: 2024 May 17.
Published in final edited form as: J Med Chem. 2023 Jan 20;66(3):1809–1834. doi: 10.1021/acs.jmedchem.2c01624

Figure 5. Dose-dependent effects of 13a on cocaine self-administration.

Figure 5.

(A) Mean numbers after different doses of 13a administration. (B) Mean numbers of inactive lever presses after different doses of 13a pretreatments. (C) Representative cocaine infusions behavior indicating an extinction-like pattern of cocaine self-administration after 13a administration in a way similar to cariprazine. (*p < 0.05, **p < 0.01, ***p < 0.001, compared to the vehicle control group).