Extended Data Figure 8. Proteoglycan expression profile in human clear cell renal cell carcinomas (ccRCCs) and adjacent kidney.

a. Violin plot showing the relative levels of cholesterol in ccRCC patient tissues (blue) compared to paired adjacent kidney (grey).

b. Violin plot showing the relative levels of total heparan sulfate (HS) per gram of protein in ccRCC patient tissues (blue) compared to paired adjacent kidney (grey).

c. Heatmap showing expression of individual proteoglycan genes in ccRCC tumours and paired adjacent kidney. Each sample was assigned a proteoglycan score, based on their expression of all proteoglycans (top). Relevant proteoglycans scoring are highlighted in blue.

a, b, n=17–20 biologically independent samples. Statistical significance was determined by a two-tailed unpaired t-test.