Table 1.

Clinical studies reporting withdrawal of GLP-1RA.

GLP-1RA used	Period of study	Weight loss observed (%)	Weight gain after withdrawal/continuity/placebo	Observations	References
Semaglutide	68 weeks	17.3	11.6	Withdrawal led to most of the weight loss with regain in 12 years. Cardiometabolic variables back to baseline requiring the need for continuous treatment	Lopez-Jimenez et al. [4]
Liraglutide	68 weeks (including 12 week off drug period)	6	1.9%	Liraglutide-induced weight loss combined with caloric restriction and lifestyle modification	Wadden et al. [52]
Semaglutide	20–68-week switch to placebo	7.9	6.9%	Maintaining treatment with semaglutide compared with switching to placebo resulted in continued weight loss over the following 48 weeks	Rubino et al. [53]
Liraglutide	54 weeks	5–10	At study end, weight had increased 0.53 kg with orlistat	In combination with diet, exercise, and behavioral modification, orlistat improved weight management in overweight adolescents compared with placebo	Le Roux et al. [54]