Table 1.

Major associations with LTL. Effect sizes with 95% confidence intervals (CI) from a joint linear regression model for traits with less than 7% missing data retained as significant LTL predictors by Lasso analysis. EA = educational attainment; IGF-1 = insulin-like growth factor 1; WHR = waist-to-hip ratio; MCH = mean corpuscular hemoglobin

Trait	Estimate	Lower 95% CI	Upper 95% CI	P-value
Female	0.071	0.066	0.077	$2.33\times {10}^{\text{-}160}$
EA	0.042	0.038	0.046	$1.95\times {10}^{\text{-}111}$
IGF-1	0.028	0.024	0.032	$3.57\times {10}^{\text{-}49}$
WHR	$\text{-}0.002$	$\text{-}0.007$	0.004	$5.43\times {10}^{\text{-}1}$
Urate	$\text{-}0.009$	$\text{-}0.014$	$\text{-}0.004$	$1.16\times {10}^{\text{-}4}$
Monocyte count	$\text{-}0.017$	$\text{-}0.021$	$\text{-}0.013$	$4.89\times {10}^{\text{-}17}$
Eosinophil count	$\text{-}0.021$	$\text{-}0.025$	$\text{-}0.017$	$1.00\times {10}^{\text{-}28}$
Cystatin C	$\text{-}0.026$	$\text{-}0.030$	$\text{-}0.022$	$4.93\times {10}^{\text{-}33}$
Lymphocyte count	$\text{-}0.039$	$\text{-}0.043$	$\text{-}0.035$	$7.43\times {10}^{\text{-}87}$
MCH	$\text{-}0.058$	$\text{-}0.062$	$\text{-}0.055$	$4.98\times {10}^{\text{-}223}$
Age	$\text{-}0.155$	$\text{-}0.159$	$\text{-}0.151$	$<2.2\times {10}^{\text{-}308}$