Table 4.
Hazard ratio for recurrence-free survival, recurrence, and overall survival in the total population and subgroups according to Digistain Prognostic Score-based risk multivariable model high-low classification
| Total population | Lymph node negative | Lymph node positive | Age ≤ 50 years (premenopausal) | Age ≥ 60 years (postmenopausal) | |
|---|---|---|---|---|---|
| Hazard ratio (95%CI) | |||||
| Recurrence-free survival |
1.80 (1.31–2.48) P < 0.001 |
1.63 (1.08–2.48) P = 0.021 |
1.48 (0.81–2.71) P = 0.202 |
1.91 (1.11–3.28) P = 0.019 |
1.99 (1.18–3.34) P < 0.001 |
| N–low-risk | 391 (49.18%) | 335 (61.14%) | 56 (22.49%) | 116 (47.54%) | 166 (56.08%) |
| N—high-risk | 404 (50.82%) | 211 (38.64%) | 193 (77.51%) | 128 (52.46%) | 130 (43.91%) |
| Recurrence |
1.83 (1.32–2.52) P < 0.001 |
1.61 (1.06–2.47) P = 0.027 |
1.55 (0.83–2.89) P = 0.168 |
2.06 (1.18–3.60) P = 0.011 |
2.22 (1.31–3.74) P = 0.002 |
| N—low-risk | 394 (49.56%) | 341 (62.45%) | 53 (21.29%) | 114 (46.72%) | 170 (57.43%) |
| N—high-risk | 401 (50.44%) | 205 (37.55%) | 196 (78.71%) | 130 (53.28%) | 126 (42.56%) |
| Overall survival |
1.77 (1.28–2.43) P < 0.001 |
1.38 (0.92–2.07) P = 0.124 |
1.67 (0.88–3.15) P = 0.116 |
2.16 (1.09–4.28) P = 0.028 |
1.66 (1.08–2.57) P = 0.022 |
| N—low-risk | 349 (43.90%) | 304 (55.68%) | 45 (18.07%) | 100 (40.98%) | 147 (49.66%) |
| N—high-risk | 446 (56.10%) | 242 (44.32%) | 204 (81.93%) | 144 (59.02%) | 149 (50.34%) |