Table 3.
Bladder cancer risk (Odd Ratio [OR] and 95% confidence intervals) by quartiles of methylation methylation level at cg05575921 (AHHR) and the first principal component (PC1) summarising the methylation levels at the 200 smoking-related CpG site
| Crude Modela | Adjusted on pack-years | Adjusted on duration (years) | Adjusted on intensity (packs/day) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | p-value | OR | p-value | OR | p-value | OR | p-value | ||
| cg05575921 (AHRR) | Q2 vs Q1 | 1.41 (1.08, 1.85) | 1.3e − 02 | 1.36 (1.04, 1.79) | 2.6e − 02 | 1.36 (1.04, 1.79) | 2.6e − 02 | 1.39 (1.06, 1.82) | 1.8e − 02 |
| Q3 vs Q1 | 1.47 (1.12, 1.93) | 5.4e − 03 | 1.29 (1.03, 1.7) | 7.8e − 02 | 1.20 (1.12, 1.6) | 2.3e − 01 | 1.39 (1.06, 1.84) | 1.8e − 02 | |
| Q4 vs Q1 | 2.58 (1.91, 3.48) | 5.7e − 10 | 1.87 (1.34, 2.62) | 2.8e − 04 | 1.47 (1, 2.19) | 5.2e − 02 | 2.09 (1.52, 2.89) | 7.5e − 06 | |
| PC1b | Q2 vs Q1 | 1.25 (1.04, 1.63) | 1.0e − 01 | 1.18 (1.11, 1.54) | 2.3e − 01 | 1.18 (1.11, 1.54) | 2.2e − 01 | 1.21 (1.08, 1.57) | 1.7e − 01 |
| Q3 vs Q1 | 1.89 (1.43, 2.5) | 9.5e − 06 | 1.64 (1.23, 2.19) | 8.7e − 04 | 1.58 (1.18, 2.12) | 2.1e − 03 | 1.75 (1.31, 2.33) | 1.3e − 04 | |
| Q4 vs Q1 | 2.48 (1.85, 3.34) | 1.6e − 09 | 1.90 (1.38, 2.63) | 9.2e − 05 | 1.63 (1.15, 2.32) | 6.3e − 03 | 2.07 (1.52, 2.84) | 4.5e − 06 | |
Results are also presented for the model additionally adjusted for smoking metrics
Number of observations per quartile:
cg055792: Q1 (n = 386); Q2: (n = 386); Q3 (n = 386); Q4: (n = 387)
PC1: Q1 (n = 386); Q2: (n = 386); Q3 (n = 386); Q4: (n = 387)
aAll models were adjusted for age, sex and centre
bPC1 explains 19.3% of the total variance