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. 2024 May 17;14:11271. doi: 10.1038/s41598-024-61961-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ROC curves showing the performance to predict lesional progression of (A) lesional SUV_max on the baseline [⁶⁸Ga]Ga-PSMA-11 PET/CT scan or (B) FPQ, [¹⁸F]FDG SUV_max /[⁶⁸Ga]Ga-PSMA-11 SUV_max quotient. The respective maximum values (J) of the Youden's index identified a [⁶⁸Ga]Ga-PSMA-11 SUV_max of < 11.09 (sensitivity 88.2%, specificity 81.9%) or an FPQ of ≥ 0.92 (sensitivity 90.2%, specificity 78.7%) as optimal threshholds.