Fig. 3. The interface between L an P of MuV polymerase complex.
a Overall view of tetrameric P bound to RdRp of L. P1, P2, P3, and P4 are colored in magenta, light pink, plum, and dark violet, respectively. Four core interaction zones are boxed with white dotted rectangles. b–e, Close-up views of the interaction zones i, ii, iii, and iv. Hydrogen bonds and salt bridges are indicated by dim gray and red dashed lines, respectively. Residues involved in hydrophobic interactions are colored in brown. f Sequence alignment of P from six MuV strains spanning residues 191–320. Solid lines beneath the sequences represent the structurally resolved regions. Dashed lines represent the unsolved regions. Labels of secondary structures above the sequences are based on the atomic model of P4. Gly246, the kink between helices α1 and α2 of POD, is labeled.