Table 2.
Overview of the applied biomarker panel, the targeted peptide sequences, and the biological functions
| Protein | Abbreviation | Accession | Sequence | Function |
|---|---|---|---|---|
| Neurosecretory protein VGF | VGF | O15240 | AYQGVAAPFPK | Neurotransmitter secretion |
| NSEPQDEGELFQGVDPR | ||||
| Neuronal pentraxin receptor | NPTXR | O95502 | NNYMYAR | Glutamate receptor recruitment; synaptic plasticity |
| LVEAFGGATK | ||||
| Neuronal pentraxin-1 | NPTX1 | Q15818 | ETVLQQK | |
| CESQSTLDPGAGEAR | ||||
| Neuronal pentraxin-2 | NPTX2 | P47972 | VAELEDEK | |
| ETVVQQK | ||||
| Amyloid-beta precursor protein | APP | P05067 | VESLEQEAANER | Neuronal surface receptor |
| Secretogranin-2 | SCG2 | P13521 | ALEYIENLR | Neuroendocrine protein, biogenesis of secretory granules |
| VLEYLNQEK | ||||
| Neurogranin | NEUG | Q92686 | KGPGPGGPGGAGVAR | Binds calmodulin, enhances synaptic transmission |
| Syntaxin-7 | STX7 | O15400 | EFGSLPTTPSEQR | Vesicle trafficking |
| Syntaxin-1B | STX1B | P61266 | QHSAILAAPNPDEK | |
| AP-2 complex subunit beta | AP2B1 | P63010 | AVWLPAVK | Mediating endocytosis |
| IQPGNPNYTLSLK | ||||
| QVFLATWK | ||||
| Chromogranin-A | CMGA | P10645 | GLSAEPGWQAK | Aggregation and processing of secretory granules |
| EDSLEAGLPLQVR | ||||
| GangliosideGM2 activator | SAP3 | P17900 | EVAGLWIK | Binding gangliosides, stimulating GM2 degradation |
| IESVLSSSGK | ||||
| β-synuclein | SYUB | Q16143 | EGVVQGVASVAEK | Presynaptic functioning |
| γ-synuclein | SYUG | O76070 | ENVVQSVTSVAEK | |
| Complexin-2 | CPLX2 | Q6PUV4 | AALEQPCEGSLTRPK | Vesicle trafficking |
| Rab GDP dissociation inhibitor alpha | GDIA | P31150 | QLICDPSYIPDR | Vesicle trafficking |
| Phosphatidylethanolamine-binding protein 1 | PEBP1 | P30086 | NRPTSISWDGLDSGK | Regulatory protein, presynaptic functioning |
| LYEQLSGK | ||||
| Lysosome-associated membrane glycoprotein 2 | LAMP2 | P13473 | IPLNDLFR | Chaperone-mediated autophagy |
| Cathepsin-F | CATF | Q9UBX1 | TLLCSFQVLDELGR | Protein turnover, intracellular degradation |
| 1433E | 1433E | P62258 | IISSIEQK | Adapter proteins, modulating general and specific pathways by activity regulation of the binding partners |
| 1433 F | 1433 F | Q04917 | AVTELNEPLSNEDR | |
| 1433 T | 1433 T | P27348 | AVTEQGAELSNEER | |
| 1433Z | 1433Z | P63104 | VVSSIEQK |