Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 May 17;24(1):101. doi: 10.1007/s10238-024-01365-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — Mechanism of action of MUC16 in pancreatic cancer. Interacting with Mesothelin, MUC16 enhances MMP7 expression via p38MAPK phosphorylation. Sialosylated MUC16 binds E- and L-selectin, promoting adhesion to host tissues. galectin binding facilitates PDAC cell metastasis.MUC16-Cter induces JAK2 nuclear shift, upregulating LMO2 and NANOG. Cytoplasmic MUC16c release activates IL-6 secretion through JAK2/STAT3.Cytoskeletal proteins (Actg2, MYH11, Pdlim3) are upregulated, altering the tumor microenvironment. NRP2 upregulation via JAK2/STAT1 promotes metastasis.MUC16 binds FAK, activating downstream AKT and ERK/MAPK. Truncated O-glycochains interact with integrins, activating ILK.c-Myc regulates MUC16 expression transcriptionally, and forming a feedback loop.MiR-29a antagonizes MUC16-mediated migration and invasion