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. 2024 May 17;24(1):101. doi: 10.1007/s10238-024-01365-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — MUC16-mediated inhibition of NK cells in epithelial ovarian cancer. Shed MUC16 (sMUC16) binds to NK cells via Siglec-9, initiating immune suppression prior to NK cell tumor-killing. Cell surface MUC16 (csMUC16) reduces NK cell-cancer cell proximity, diminishing their binding and impairing NK cell-mediated tumor cell killing