Table 1.
Ethanol-induced upregulation of TLR7 and IRF7 in human and rodent brain.
| Upregulation of TLR7 | ||
| Human AUD | Hippocampus | Coleman et al. (2017) |
| Human AUD | Cortex, orbitofrontal | Qin et al. (2021) |
| Mouse binge ethanol | Hippocampal-entorhinal cortex slice culture | Qin et al. (2021) |
| Mouse 2BC-EOD | Cortex, prefrontal | Erickson et al. (2018) |
| Rat in vitro ethanol | Hippocampal-entorhinal cortex slice culture | Coleman et al. (2017) |
| Upregulation of IRF7 | ||
| Human AUD | Cortex, orbitofrontal | Qin et al. (2021) |
| Human AUD | Cortex, dorsolateral | Kapoor et al. (2019) |
| Mouse 2BC-EOD | Cortex, prefrontal (astrocytes) | Erickson et al. (2018) |
| Mouse CIE | Cortex, prefrontal (astrocytes) | Erickson et al., 2019a |
| Mouse CIE | Cortex, prefrontal (microglia) | Erickson et al., 2019b |
| Mouse 2BC-CIE-Stress | Cortex, prefrontal | Farris et al. (2020) |
| Mouse binge ethanol | Cortex, orbitofrontal and entorhinal | Qin et al. (2021) |