Figure 2.

Adjusted associations between categories of normalized ALP and normalized PTH and time-to-event clinical outcomes. Cox models stratified by DOPPS phase and country, adjusted for demographics: age, sex, Black race, dialysis vintage, 13 comorbid conditions, single pool Kt/V, body mass index, serum albumin, serum creatinine, hemoglobin. (a) All cause mortality, (b) cardiovascular mortality, (c) non-cardiovascular mortality, (d) bone fracture, and (e) hip fracture. Reference group = normalized ALP: 0.75–0.99 and normalized PTH: 3–5.9. Sample sizes for each cell are provided in Supplementary Table S4. ALP, alkaline phosphatase; DOPPS, Dialysis Outcomes and Practice Patterns Study; PTH, parathyroid hormone.