Table 6.

Confirmatory analysis for idiopathic calcium stone formers – logistic regression analysis

Outcome variables	N obs	Vitamin D Metabolite Diagnostic Ratio
		OR	95% CI	P-value
Total calcium oxalate	595	0.844	0.668, 1.067	0.157
Calcium oxalate monohydrate	588	0.404	0.258, 0.632	<0.001
Calcium oxalate dihydrate	588	1.62	1.147, 2.289	0.006

BMI, body mass index; dRTA, distal renal tubular acidosis; eGFR, estimated glomerular filtration rate

Multivariable logistic regression between Vitamin D metabolite diagnostic ratio with relative kidney stone composition analysis ≥ 50%. Multivariable model adjusted for age, sex, BMI, eGFR, 25(OH) vitamin D₃, urinary sodium excretion, loop and thiazide diuretics, and medications that interfere with plasma 25(OH) Vitamin D3 concentration. Non-calcium stone formers, patients without available stone analysis and with secondary causes for kidney stones were excluded (primary hyperparathyroidism, sarcoidosis, complete dRTA, primary or enteric hyperoxaluria). Number of observations (N obs), Odds ratios (OR), 95% confidence intervals (95% CI) and P-values are indicated for each comparison.