Figure 1.

(a) Histopathological analysis of the native liver specimen by hematoxylin and eosin staining revealing a normal parenchyma with sinusoid capillaries obstructed by small clusters of red blood (green arrows) and myeloid precursors as well as scattered megakaryocytes (dashed blue arrows) consistent with extramedullary hematopoiesis. (b) Bone marrow biopsy showing diffuse oxalate crystals deposits that appears highly birefringent on polarized light microscopy (inset) combined with severe alterations of the bone marrow architecture (not shown), consistent with bone marrow failure. (c) (Left) Contrast-enhanced abdominal computed tomography-scan showing massive splenomegaly (red asterisk); (Right) ¹¹¹In-chloride scintigraphy showed a marked reduction in the uptake of the tracer by the marrow, and a significant uptake by the spleen, consistent with the diagnosis of bone marrow failure and spleen extramedullary erythropoiesis.