Table 3.

In vivo oral efficacy of selected robenidine derivatives. Four mice received either 200 mg/kg of 1 or 100 mg/kg of 19 through an oral gavage.

Compound	Dose [mg/kg]	Number of mice cured/treated	Mean number of worms (SD)	Worm burden reduction [%] (SD)	p-value
1	200	0/4	24.3 (4.3)	14 (15)	0.15
19	100	0/4	28.3 (10.6)	0 (38)	0.88
Control	–	–	28.0 (4.3)	–	–

The worm burden reduction was calculated by comparing the number of worms found in the control mice versus treated mice.