Table 4.

Parameters from serial echocardiography on WT and S14A mice at 5 months

	WT		S14A/S14A
	Male (n=11)	Female (n=12)	Male (n=11)	Female (n=10)
BW (g)	33.9±4.3	25.4±3.2*	33.0±3.7	28.8±5.2
LV mass (mg)	145.0±21.0	103.9±18.3	129.2±12.4	115.7±21.0
LV mass/BW (mg/g)	4.28±0.46	4.08±0.41	3.94±0.36	4.06±0.63
HR (bpm)	458±33	452±24	463±25	462±28
EF (%)	43.34±5.64	46.98±8.92	42.85±9.65	45.72±5.88
FS (%)	21.42±3.33	23.59±5.86	21.21±5.42	22.68±3.43
SV (μl)	43.54±8.42	38.47±5.34	39.91±6.03	38.64±4.88
CO (ml/min)	20.00±4.33	17.34±2.09	18.42±2.64	17.87±2.73
LVPW;d (mm)	0.739±0.086	0.634±0.057	0.691±0.051	0.680±0.092
LVPW;s (mm)	0.987±0.077	0.879±0.077	0.945±0.121	0.917±0.099
LVID;d (mm)	4.651±0.178	4.289±0.220**	4.550±0.312	4.334±0.162
LVID;s (mm)	3.653±0.165	3.284±0.359	3.596±0.463	3.353±0.223
LVEDV (μl)	100.07±9.16	82.86±9.98**	95.49±15.75	84.81±7.48
LVESV (μl)	56.53±6.08	44.39±10.30	55.58±17.46	46.17±7.39
LVAW;d (mm)	0.808±0.116	0.690±0.088	0.769±0.096	0.742±0.135
LVAW;s (mm)	1.107±0.169	0.998±0.079	1.044±0.165	1.052±0.208

Mean ± SD; repeated three-way ANOVA followed by Tukey’s test.

^*P<0.05 vs. male mice with same genotype.

^**P<0.01 vs. male mice with same genotype.