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. Author manuscript; available in PMC: 2024 May 18.
Published in final edited form as: Cell Rep. 2024 Apr 4;43(4):114029. doi: 10.1016/j.celrep.2024.114029

Figure 3. Sebum phenotypes are transmitted to progeny transgenerationally from GF mice.

Figure 3.

(A and B) TLC quantification of hair wax esters from (A) CR or GF mice from the UNC gnotobiotic core (n = 3 or 4 mice/group) and (B) CR or GF Swiss-Webster mice (n = 4 or 5 mice/group).

(C) Breeding scheme for transgenerational experiments.

(D–G) TLC quantification of hair wax esters from the progeny of combinatorial CR and GF natural breeding in the (D) F1 (n = 13 to 17 mice/group, two F0 breeding pairs/group) and (E) F2 (n = 7 to 27 mice/group, two F1 breeding pairs/group) generations and mice derived from IVF and the resulting (F) F1 (n = 3 mice/group) and (G) F2 (n = 6 or 22 mice/group) generations.

All experiments performed 2–3 times. **p < 0.01, ***p < 0.001 by Student’s t test. Data are shown as mean ± SD.

See also Figure S3.