. 2024 May 18;23:107. doi: 10.1186/s12943-024-02004-z

Table 1.

Comparison of basic features of classical neutrophils and polymorphonuclear myeloid derived suppressor cells (PMN-MDSCs)

Characteristic	Neutrophils	PMN-MDSCs	References
Activation effects	Host infection with bacteria or pathogens	Long-term chronic inflammation, autoimmune diseases and cancer	[11]
Mutagenic factors	G-CSF, GM-CSF	G-CSF, GM-CSF, IL-6, IL-8, TGF-β, leukotriene B4	[12–17, 19, 20]
Cell surface marker	CD14⁻CD15⁺CD66b⁺CD16⁺	CD14⁻CD15⁺CD66b⁺CD16⁺CD11b⁺CD33⁺HLA-DR⁻	[21–24]
New specific biomarkers	c-Kit^hiCXCR2^hiCD101^hi	LOX1^hiFATP2^hiArg-1^hiCD300ld^hi	[25–30]
Nuclear morphology	Segmented nucleus	Banded nucleus	[31]
Mature state	Mature	Immaturate	[31]
Density centrifugation	High-density cells	Low-density cells	[31]