Table 3.

Evidence overview – aortic surgery

No	Study	Study design	Device	Interventions	Controls	Results of the intervention
1	2019 Saller, T., et al. [25]	Retrospective Case–control (PSM) Procedure: Aortic surgery with hypothermic circulatory arrest	CytoSorb® (intra-op on CPB)	168	168	Significantly: - lower requirement for intraoperative norepinephrine - less pRBC & FFP transfusions - higher requirement for PCC Notably: - improved acid–base balance - lower intraoperative mortality
2	2021 Mehta, Y., et al. [26]	Retrospective Case–control Procedure: Ascending aorta replacement	CytoSorb® (intra-op on CPB)	8	8	Significantly: - lower IL-6 (primary outcome) - requirement for norepinephrine - ICU and hospital stay Notably: - improved PaO2/FiO2 ratio - duration of mechanical ventilation No significant differences in primary outcomes PCT, WBC count, and CRP
3	2023 Doukas, P., et al	Prospective RCT Procedure: Thoracoabdominal aortic repair	CytoSorb® (intra-op on CPB)	10	17	Significantly: - lower incidence of severe ARDS Notably: - shorter duration of mechanical ventilation

PSM Propensity score matching, CPB Cardiopulmonary bypass, pRBC Packed red blood cells, FFP Fresh frozen plasma, PCC Prothrombin complex concentrate, IL Interleukin, ICU Intensive care unit, PCT Procalcitonin, WBC White blood cells, CRP C reactive protein, RCT Randomized controlled trial, ARDS Acute respiratory distress syndrome