Table 4.

Model 3 results for the blood biomarkers and the imaging biomarkers

	Serum NfL			Plasma NTA			Plasma t-tau			Plasma GFAP
	R2 = 0.22 p = 0.017			R2 = 0.18 p = 0.021			R2 = 0.083 p = 0.14			R2 = 0.18 p = 0.023
Predictors	Estimate	F ratio	Std β	Estimate	F ratio	Std β	Estimate	F ratio	Std β	Estimate	F ratio	Std β
WMH, slope (95% CI)	0.0098 (0.0029 to 0.017)**	8.12	0.34	0.0015 (-0.015 to 0.022)	0.032	0.022	-0.0047 (-0.012 to 0.0030)	1.51	-0.16	0.0039 (-0.0041 to 0.12)	0.95	0.12
MTA, slope (95% CI)	0.12 (0.0044 to 0.23)*	4.34	0.25	0.45 (0.13 to 0.76)**	8.10	0.37	0.09 (-0.042 to 0.22)	1.85	0.18	0.16 ( 0.020 to 0.29)*	5.29	0.29
PiB, slope (95% CI)	0.058 (-0.11 to 0.23)	0.85	0.11	-0.11 (-0.51 to 0.76)	0.28	-0.068	0.017 (-0.17 to 0.21)	0.032	0.025	0.22 (0.028 to 0.42)*	5.27	0.29

Serum NfL = neurofilament light, Plasma NTA = N-terminal tau marker, Plasma t-tau = Quanterix total tau marker, Plasma GFAP = glial fibrillary acidic protein, WMH = volumes of white matter hyperintensities, MTA = medial temporal lobe atrophy score, PiB = [¹¹C]PiB composite score, Blood biomarker values are log transformed, Results adjusted for MRI scanner. P-values are FDR-corrected including all p-values from tables 1, 2, 3, and 4. Significant values are bolded

Blood biomarker values were log transformed. *p < 0.05. **p < 0.01. ***p < 0.001