TABLE 1.

List of published studies from which metabolic fluxes were derived for use in Figure 2 (fluxes with associated standard deviation in μmol/g/min). These studies were selected for having independently determined V_PC, V_NT, and TCA cycle rates in neurons (V_TCAⁿ) and astrocytes (V_TCA^a).

	VNT	VPC	CMRglc(ox)
Human
Gruetter et al. (2001)	0.17 ± 0.05	0.09 ± 0.02	0.36 ± 0.08
Rat
Choi et al. (2002) (isoelectricity)	0.04 ± 0.01	0.03 ± 0.01	0.32 ± 0.07
Öz et al. (2004) (awake)	0.57 ± 0.21	0.14 ± 0.03	0.84 ± 0.17
Duarte et al. (2011)	0.11 ± 0.01	0.069 ± 0.004	0.39 ± 0.02
Jeffrey et al. (2013)	0.12 ± 0.05	0.07 ± 0.02	0.38 ± 0.08
Duarte and Gruetter (2013) a	0.24 ± 0.01	0.092 ± 0.005	0.47 ± 0.02
Lanz et al. (2014)	0.15 ± 0.01	0.09 ± 0.01	0.41 ± 0.06
Sonnay et al. (2016) (rest)	0.070 ± 0.014	0.064 ± 0.005	0.45 ± 0.02
Sonnay et al. (2016) (stimulation)b	0.137 ± 0.027	0.069 ± 0.011	0.52 ± 0.05
Sonnay et al. (2017) (isoelectricity)	0.092 ± 0.023	0.023 ± 0.004	0.32 ± 0.01
Girault et al. (2019)	0.20 ± 0.02	0.09 ± 0.01	0.37 ± 0.03
Tree shrew
Sonnay et al. (2017) (rest)	0.19 ± 0.023	0.074 ± 0.008	0.43 ± 0.02
Sonnay et al. (2017) stimulation)b	0.23 ± 0.040	0.066 ± 0.006	0.49 ± 0.02
Mouse
Lai et al. (2018)	0.084 ± 0.008	0.041 ± 0.003	0.38 ± 0.02

^aData included labelling of GABA and was modelled with a 3-compartment model (other studies included only glutamate, glutamine, and/or aspartate).

^bUsed only in panel D.