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. 2024 May 18;15:4235. doi: 10.1038/s41467-024-48589-3

Fig. 7. High expression of SPARCL1 in COVID-19 patients correlates with increased mortality.

Fig. 7

A Representative immunostaining image of SPARCL1 in endothelial cells (ERG) in both healthy and COVID-19 donors’ lung tissue. Scale bar, 50 μm. B qPCR analysis of SPARCL1 in isolated lung ECs (CD45−EpCAM−CD31+) sorted from both healthy (n = 5) and COVID-19 (n = 4) donors’ lung tissue, p = 0.013. C The SPARCL1 level in plasma from COVID-19 patients was measured by Olink proximal extension assay. For each group, the box depicts the median (center line) and upper and lower quartile. Upper quartile = 75th percentile and lower quartile = 25th percentile of the data. Data are presented as means ± SEM, Data in B were calculated using unpaired two-tailed t-test; Data in C were calculated using 2-sided, Wilcoxon Rank sum test comparing 90-day survivors (n = 131) to 90-day non-survivors (n = 28), *P < 0.05. Source data are provided as a Source Data file.