Skip to main content
. 2024 May 18;15:4224. doi: 10.1038/s41467-024-48414-x

Fig. 3. Antibody and T-cell responses after different original priming and bivalent booster vaccinations.

Fig. 3

a–f Detection of (ancestral) spike (S)-specific binding IgG antibodies (a, b), ancestral SARS-CoV-2 neutralizing antibodies (c, d), and T-cell responses measured by interferon-gamma (IFN-γ) release assay (IGRA) (e, f) based on the different combinations of original priming regimen after Omicron BA.1 (a, c, e) or BA.5 (b, d, f) bivalent booster vaccination at baseline, and 7 days, 28 days, and 3 months post-boost. Colors indicate the specific prime-boost regimen (orange = Ad26.COV2.S prime, BNT162b2 Omicron BA.1 or BA.5 boost; yellow = Ad26.COV2.S prime, mRNA-1273.214 or mRNA-1273.222 boost; dark blue = mRNA-based prime, BNT162b2 Omicron BA.1 or BA.5 boost; light blue = mRNA-based prime, mRNA-1273.214 or mRNA-1273.222 boost). Data are shown in box-and-whisker plots, with the horizontal lines indicating the median, the bounds of the boxes indicating the interquartile range (IQR), and the whiskers indicating the range. Bold numbers above the plots represent the respective geometric mean (titer) per timepoint. The line graphs next to each panel depict a time course of the respective geometric mean values with 95% confidence intervals. The number of biologically independent samples (serum or whole blood) used per assay is shown in Supplementary Table S4.