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. Author manuscript; available in PMC: 2024 Jul 18.
Published in final edited form as: Mol Cell. 2023 Dec 15;84(2):375–385.e7. doi: 10.1016/j.molcel.2023.11.026

Figure 3. Acb2 binds to cyclic trinucleotides and dinucleotides simultaneously.

Figure 3.

(A) Overall structure of Acb2 complexed with cA3 and 3’,3’-cGAMP. cA3 and 3’,3’-cGAMP are shown as blue and light gray sticks. Two views are shown.

(B) 2Fo-Fc electron density of cA3 and 3’,3’-cGAMP within an Acb2 dimer contoured at 1 σ.

(C) Distribution of the small molecules within the Acb2 hexamer. The nucleotides are shown as they are in the right panel of (A).