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. 2024 May 15;18:1583–1602. doi: 10.2147/DDDT.S455006

Figure 3.

Figure 3

RAR decelerated cartilage degeneration and enhanced ECM anabolism in OA rats. (A) Rat knee joints scanned in 3D after RAR and PC therapy at several doses using Micro-CT. The red arrows indicate surface irregularities and cracks in the knee joints. (BD) BV/TV, Tb.Th, and Tb.Sp quantitative analysis. (E) Rats’ right knee joint stained with safranin-O-solid green (S&F). Col2a1 and Acan in cartilage stained with IHC. Scale bar=200 μm. (F) OARSI score of the tibial plateau. (G and H) Quantification of the percentage of positive expression of Col2a1 (%) and Acan (%). (I) Relative mRNA expression of Acan, Comp, and Col2a1 in DMM rats treated with RAR and PC. All data are presented as the means ± standard deviations (n=10). Sham vs DMM, ###P < 0.001; DMM vs RAR/PC, *P <0.05, **P <0.01, ***P <0.001.