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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: J Allergy Clin Immunol. 2023 Aug 29;152(6):1550–1568. doi: 10.1016/j.jaci.2023.07.021

Figure 8: A novel esophageal epithelial cell cluster present exclusively in Active EoE scRNAseq samples is a potent source of SFRP1.

Figure 8:

A. Sub-clustering of the integrated and combined “Epithelial Cell” cluster identified in Fig 7B into six predominant subpopulations B. Sub-clustered epithelial populations separated by disease state (Active, Normal, Remission) and identification of a seventh sub-population in the “Active” samples. C. SFRP1 mRNA expression in epithelial subpopulations separated by disease state (Active, Normal, Remission) D. Mapping of 560 genes expressed in the seventh epithelial subpopulation present in Active disease, upon the top 100 “Basal” and “Suprabasal” markers E. Network of top 50 differentially expressed genes present in the Disease-Associated epithelial population, depicting canonical genes highly differentially expressed in EoE (green). F-I. mRNA expression of EoE pro-inflammatory genes CCL26, ALOX15, TNFAIP6, and POSTN in the Disease-Associated epithelial population.