Table 2.
Differences and commonalities in white matter microstructure between individuals with or at risk for BD and HV that met criterion for robustness.
| Peak MNI coordinate | Voxels | P | Hemisphere | Regions |
|---|---|---|---|---|
|
| ||||
| Individuals with BD | ||||
| Fractional anisotropy: BD < HV | ||||
| 24, 34, 8 | 2089 | <.00001 | R | CC, ATR |
| −42, −50, 36 | 42 | .00007 | L | SLF |
| 14, 40, 36 | 33 | .00001 | R | CC |
| 20, −46, 54 | 22 | .00001 | R | CC |
| 12, 0, −10 | 31 | .00025 | R | Inter-striatal WM |
| Radial diffusivity: BD > HV | ||||
| 24, 34, 8 | 603 | <.00001 | R | ATR, CC |
| 26, −20, 34 | 101 | <.00001 | R | CST |
| −30, −18, 34 | 48 | .00013 | L | SLF |
| 16, 32, −16 | 38 | .00008 | R | FOP |
| Conjunction: Reduced FA ^ Increased RD | ||||
| 23, 34, 8 | 458 | <.005 | R | ATR, CC |
| 21, −19, 36 | 25 | <.005 | R | SLF |
| 15, 32, −11 | 21 | <.005 | R | FOP |
| Individuals at risk for BD | ||||
| Fractional anisotropy: AR < HV | ||||
| 26, −56, 24 | 80 | <.00001 | R | CC body |
| −12, −32, 26 | 52 | .00024 | L | CC splenium |
| −24, −20, 34 | 37 | .00047 | L | CST |
| Endophenotype | ||||
| Decreased fractional anisotropy: (BD < HV) ^ (AR < HV) | ||||
| −12, −31, 26 | 52 | <.005 | L | CC splenium |
| 25, −53, 20 | 39 | <.005 | R | CC body |
| Disease marker | ||||
| Fractional anisotropy: BD < AR = HV | ||||
| 2, −10, 6 | 83 | <.00001 | R | ATR |
Abbreviations: AR, at risk; ATR, anterior thalamic radiations; BD, bipolar disorder; CC, corpus callosum; CST, corticospinal tract; FA, fractional anisotropy; FOP, fronto-orbito-polar tract; HV, healthy volunteers; L, left; R, right; RD, radial diffusivity; SLF, superior longitudinal fasciculus.