Table 3.

Meta-regression findings on effect of mean age, sex (% female), affective symptoms, and medication status on FA in BD individuals compared to HV. Number of studies and total sample size are reported in parentheses.

	Peak MNI coordinate	Voxels	P	Regions	Peak MNI coordinate	Voxels	P	Regions
AGE	Positive age effect (57 studies, N = 4631)				Negative age effect (57 studies, N = 4631)
	28, −18, 14	29	.00008	CST, SLF	−6, −14, 26	158	<.00001	CC
	32, −14, 34	28	.00022	SLF	−32, −60, 14	62	<.00001	CC
	−20, 22, −2	26	.00033	FOP
SEX	Males < Females (57 studies, N = 4631)				Males > Females (57 studies, N = 4631)
	32, −66, 10	52	.00001	CC	18, 30, −10	63	.00041	FOP
	50, −20, 2	50	.00001	AF	16, 36, 32	40	.00004	CC
	−28, −66, 14	25	.00001	CC	4, 30, 8	24	.00075	CC
	−46, −32, 2	28	.00003	AF	−36, −28, 44	24	.00016	SLF
SYMPTOMS	Negative relation with manic symptoms (33 studies, N = 2118)				Negative relation with depressive symptoms (30 studies, N = 1994)
	26, 16, 30	177	<.00001	CC	26, −22, 36	165	<.00001	CST
	18, −50, 58	42	.00037	CC	−20, 28, −10	107	.00003	FOP
	−20, −50, 34	30	.00058	CC	22, 36, 0	63	.00128	ATR
MEDICATIONS	Positive lithium effect (40 studies, N = 3159)				Positive antipsychotic effect (47 studies, N = 3785)
	20, 38, −6	205	.00012	CC, ATR	14, −6, −12	57	<.00001	Inter-striatal WM
	−22, 6, 18	26	.00006	ATR	14, 28, −12	53	.00001	ACR
	−16, 10, 6	20	.00015	ATR	−50, −58, 6	40	.00006	AF, ILF
	−28, −26, −8	44	.00003	ILF	14, −40, 40	21	.00002	Cingulum
	20, 32, 30	33	.00002	SLF
	−6, −38, −32	65	.00018	ATR
	4, −18, −30	30	<.00001	CST
	−30, −18, 32	24	.00027	SLF
	−46, −60, 8	22	.00016	SLF

Abbreviations: AF, arcuate fasciculus; ATR, anterior thalamic radiations; BD, bipolar disorder; CC, corpus callosum; CST, corticospinal tract; FA, fractional anisotropy; FOP, fronto-orbito-polar tract; HV, healthy volunteers; ILF, inferior longitudinal fasciculus; SLF, superior longitudinal fasciculus; WM, white matter.