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PED and BPH03 structures. (A) Schematic representation of PED primary and secondary structure (Upper) and PED NMR structure (PDB ID: 1N3K (1N3K[15])) (Lower). The 3D structure of the protein consists of a six-helices bundle N-terminal of 90 residues, a long poorly structured C-terminal tail (40 residues) hosting a small 310 helix; the N-terminal globular region constitutes the DED domain (Death Effector Domain) that includes the 6 α-helices (α1–α6). (B) 2D structure of BPH03.
