Table 1.
The role and action mechanisms of circRNAs in glycolysis in various types of cancer.
| Type of cancer | Circular RNA | Role in glycolysis | Mechanism of action | Ref |
|---|---|---|---|---|
| HCC | circBNC2 | Promotes glycolysis | The miR-217/HMGA2 axis is a mechanism by which circBNC2 promotes glycolysis and HCC stemness. | [330] |
| HCC | circRPN2 | Inhibits glycolysis | circRPN2 suppresses HCC glycolysis and spread by promoting the decomposition of ENO1 and controlling the miR-183–5p/FOXO1 pathway. | [64] |
| HCC | circUBE2D2 | Promotes glycolysis | circUBE2D2 had an oncogenic function by affecting the miR-889-3p/LDHA axis. | [50] |
| HCC | circMAT2B | Promotes Glycolysis | CircMAT2B advanced HCC development by increasing glycolysis via activating the circMAT2B/miR-338-3p/PKM2 pathway under hypoxic conditions. | [61] |
| HCC | circ_0008450 | Promotes glycolysis | By downregulating AKAP1 via miR-431, circ_0008450 suppression slowed the development of HCC in hypoxic environments. | [62] |
| HCC | circ-PRMT5 | Inhibits glycolysis | circ-PRMT5 may function as a miR-188-5p sponge to control HK2 expression. | [63] |
| HCC | circ-CFH | Promotes glycolysis | The circ-CFH/miR-377-3p/RNF38 axis mediated the development of HCC cells. | [104] |
| HCC | circRHBDD1 | Promotes Glycolysis | circRHBDD1 binds the m6A reader YTHDF1 to PIK3R1 mRNA, accelerating its translation in a m6A-dependent way. | [110] |
| HCC | circ_0000517 | Promotes Glycolysis | By regulating miR-326 and IGF1R, circ_0000517 knockdown inhibited the development of HCC in both in vitro and in vivo. | [75] |
| Liver cancer | circTUBGCP5 | Promotes Glycolysis | circ-TUBGCP5 significantly influences the aggressive characteristics and glycolysis of liver cancer by regulating the circThe TUBGCP5/miR-144-3p/ACSL4 axis | [331] |
| GC | circRPS19 | Promotes glycolysis | Through the miR-125a-5p/USP7 axis, circRPS19 stabilized the HK2 protein, causing aerobic glycolysis in GC cells and accelerating the growth of GC. | [155] |
| GC | circ_0067514 | Inhibits glycolysis | circ_0067514 inhibited the progression of GC and glycolysis by affecting the miR-654-3p/LATS2 pathway. | [332] |
| GC | circUBE2Q2 | Promotes Glycolysis | circUBE2Q2 controls GC development via the circUBE2Q2-miR-370-3p-STAT3 axis and facilitates tumor dissemination through exosomal communications. | [51] |
| GC | circ_0006089 | Promotes Glycolysis | GC development was facilitated via the circ_0006089/miR-361-3p/TGFB1 axis. | [143] |
| GC | circDNMT1 | Promotes Glycolysis | GC expansion, migration, invasion, and glycolysis were all reduced by circDNMT1 knockdown via the sponging miR-576-3p/HIF-1a axis. | [148] |
| GC | circCUL3 | Promotes Glycolysis | By controlling the STAT3/HK2 Axis, circCUL3 increases GC glycolysis development. | [140] |
| LUAD | circP4HB | Promotes Glycolysis | circP4HB may enhance the advancement of LUAD, suggesting circP4HB might be a promising treatment target for LUAD. | [179] |
| LUAD | Circ_0001777 | Inhibits glycolysis | Circ_0001777 inhibited the advancement of lung adenocarcinoma via interacting with miR-942-5p to promote PRICKLE2 expression. | [333] |
| NSCLC | circRARS | Promotes Glycolysis | circRARS can promote glycolysis and tumor progression in NSCLC by regulating LDHA. | [177] |
| NSCLC | Circ_0003028 | Promotes Glycolysis | Circ_0003028 may enhance the aggressive characteristics and glycolytic ability of NSCLC cells via a mechanism perhaps involving miR-1305 or the miR-1322/SLC5A1 axis. | [178] |
| NSCLC | circEHD2 | Promotes Glycolysis | Through the adsorption of miR-3186-3p, circEHD2 promotes FOXK1 and promotes the growth and glycolysis of NSCLC while inhibiting autophagy and apoptosis. | [169] |
| NSCLC | circSLC25A16 | Promotes Glycolysis | circSLC25A16 interacts with miR-488-3p/HIF-1α, which activates LDHA | [163] |
| NSCLC | circSHKBP1 | Promotes Glycolysis | Through the miR-1294/PKM2 axis, exosomal circSHKBP1 contributed to the advancement of NSCLC. | [173] |
| NSCLC | circ_0001421 | Promotes Glycolysis | Through modulating the miR-409-3p/TMEM14A axis, Circ 0001421 led to the development of NSCLC. | [159] |
| NSCLC | circMAGI3 | Promotes Glycolysis | circMAGI3 acted as a sponge for miR-515-5p, reducing HDGF expression and facilitating glycolysis in NSCLC. | [52] |
| NSCLC | circ_0006677 | Inhibits glycolysis | Through regulating the miR-578/SOSC2 axis, Circ 0006677 inhibits the development of NSCLC. | [165] |
| CRC | Circ_0053277 | Promotes Glycolysis | Circ_0053277 enhanced CRC cell proliferation, blood vessel formation, spread to other body parts, and glycolysis via the miR-520 h/HK1 pathway, suggesting that circ_0053277 might be a promising target for CRC therapy. | [334] |
| CRC | Circ_0087862 | Promotes Glycolysis | Circ_0087862 enhances cancer formation and glucose metabolism in CRC by acting as a decoy for miR-296-3p to control PGK1 levels. | [207] |
| CRC | circPCLE1 | Promotes Glycolysis | The miR-485-5p/ACTG1 axis is modulated by circPCLE1, which accelerates EMT, glycolysis in CRC, and M2 macrophage polarization. | [65] |
| CRC | circDENND4C | Promotes Glycolysis | circDENND4C promoted CRC cells' growth, movement, and glucose metabolism via controlling GLUT1 by acting as a sponge for miR-760. | [53] |
| CRC | circ_0136666 | Promotes Glycolysis | Circ_0136666 promoted the formation of colorectal cancer tumors using the circ_0136666/miR-383/CREB1 pathway in living organisms. | [66] |
| CRC | CircTADA2A | Inhibits glycolysis | CircTADA2A acted as a tumor suppressor in CRC by suppressing glycolysis and cell cycle progression and enhancing apoptosis of cancer cells via the miR-374a-3p/KLF14 pathway. | [67] |
| CRC | circNOX4 | Promotes Glycolysis | circNOX4 might serve as an oncogene in CRC by enhancing the growth, movement, infiltration, and glycolysis of CRC cells via the miR-485-5p/CKS1B pathway. | [197] |
| Colon cancer | circPLOD2 | Promotes Glycolysis | circPLOD2 facilitated the advancement of colon cancer by affecting the miR-513a-5p/SIX1/LDHA pathway. | [335] |
| Glioma | CircSOBP | Inhibits glycolysis | CircSOBP inhibits the advancement of glioma by interfering with glycolysis and enhancing the MDA5-mediated immune system reaction. | [237] |
| Glioma | circROBO1 | Promotes glycolysis | circROBO1 enhances glioma proliferation and resistance to enzalutamide by boosting glycolysis. | [336] |
| Glioma | CircYIPF6 | Promotes glycolysis | CircYIPF6 targets miR-760 to regulate the expression of PTBP1, influencing the proliferation, cell death, and glucose metabolism in glioma cells. | [238] |
| Glioma | CircKIF4A | Promotes glycolysis | circKIF4A promotes glioma advancement by binding to miR-335-5p and increasing ALDOA expression. | [233] |
| Glioma | circPITX1 | Promotes Glycolysis | Reducing glycolysis by CircPITX1 knockdown enhances radiation sensitivity in glioma by affecting the miR-329-3p/NEK2 axis. | [222] |
| Glioma | circHEATR5B | Inhibits glycolysis | Gymolysis and proliferation in gliomas are regulated via the ZCRB1/circHEATR5B/HEATR5B-881aa/JMJD5/PKM2 pathway. | [228] |
| CC | CircCCNB1 | Promotes Glycolysis | Downregulating CircCCNB1 inhibits the progression of CC via directing the miR-370-3p/SOX4 circuit. | [256] |
| CC | CircCDK17 | Promotes Glycolysis | In CC, reducing CircCDK17 expression increased cell death via the miR-1294/YWHAZ axis while downregulating cell growth, migration, invasion, and glycolysis. | [247] |
| CC | Hsa_circ_0018289 | Promotes Glycolysis | Hsa_circ_0018289 promotes cancer progression by controlling the miR-1294/ICMT pathway. | [252] |
| CC | circMYC | Promotes Glycolysis | circMYC enhances the development of CC via controlling the miR-577/MET axis. | [54] |
| BC | Circ-CSNK1G1 | Promotes Glycolysis | Through its regulation of the miR-28-5p/LDHA pathway, Circ-CSNK1G1 enhances cell movement, invasion, growth, and glycolysis metabolism throughout the progression of TNBC. | [270] |
| BC | circRNF20 | Promotes Glycolysis | circRNF20 sequesters miR-487a, functioning as a miRNA sponge. Subsequently, miR-487a targets the 3′-UTR of HIF-1α, which in turn binds to the promoter of HK2 and enhances its production. | [267] |
| BC | circ-RPPH1 | Promotes Glycolysis | Reducing Circ-RPPH1 inhibited aggressive cell characteristics and glycolysis via BC's miR-328-3p/HMGA2 pathway. | [279] |
| PCa | circROBO1 | Promotes Glycolysis | circROBO1 enhances PCa proliferation and resistance to enzalutamide by increasing glycolysis. | [305] |
| PCa | circLPAR3 | Promotes Glycolysis | By targeting JPT1 with microRNA-513b-5p, circular RNA LPAR3 promotes glycolytic activation while suppressing PCa radiosensitivity. | [337] |
| PCa | circTRRAP | Promotes Glycolysis | circTRRAP contributed to the advancement of PCa and glycolysis via regulating the miR-515-5p/HOXA1 pathway. | [301] |
| PCa | circMID1 | Promotes Glycolysis | circMID1 facilitated the advancement of PCa via controlling the miR-330-3p/YTHDC2/IGF1R/AKT pathway. | [293] |
| RCC | circCOL5A1 | Promotes Glycolysis | circCOL5A1 regulates the malignant behavior of RCC by modulating glycolysis. | [338] |
| RCC | Circ-CSPP1 | Promotes Glycolysis | Circular RNA CSPP1 promotes the development of RCC and glycolysis via interacting with RAC1 via microRNA-493-5p. | [339] |