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. Author manuscript; available in PMC: 2024 May 20.
Published in final edited form as: J Prev Alzheimers Dis. 2023;10(4):633–646. doi: 10.14283/jpad.2023.104

Figure 2.

Figure 2.

Senescent cell removal with D+Q improved brain structure and function in AD mice

(a) MRI on advanced aged control (CTL) and transgenic (tauNFT) mice revealed abnormal ventricles, cerebral blood flow (CBF) and white matter hyperintensity (WMH) pathologies that were mitigated by (b) treatment with DQ. Two-way ANOVA, significant treatment effect p<0.05. (c) Quantification of the number of senescence neurons with NFTs between vehicle and DQ treated mice. Two-tailed t-test, **** p < 0.0001. (d) Cognitive behavior was assessed by time spent in familiar or novel arm of the y-maze. Two-way ANOVA, Sidak post-hoc. **: p = 0.0083. n=11/group. (Adopted from (122)).