Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Senescent Cell Clearance Improves Outcomes in AD Mouse Models
| AD Pathology | Mouse Model | Senescent Cell Types | Senolytics |
|---|---|---|---|
| Tauopathy (NFTs, neurodegeneration, brain atrophy, inflammation, cognitive dysfunction) | rTg(tauP301L)4510 Mapt0/0 rTg(tauP301L)4510 rTg(tauWT)21221 |
Neurons | D+Q (35) |
| PS19 PS19-INK ATTAC |
Microglia & Astrocytes | Navitoclax (ABT263) & AP20187 (36) | |
| Aβ (Aβ plaques, inflammation, cognitive dysfunction) | Tg(APPswe, PSEN dE9) | Oligodendrocyte precursor cells | D+Q (37) |
