Table 1.

Proportion of responders for each impaired domain

	Closed-loop SCS	Open-loop SCS
Pain intensity responders (VAS overall ≥30%)	55/67 (82.1%)	49/67 (73.1%)
Risk difference (%) and 95% CI	9.0 (−5.1to 23.0), p=0.211
Physical function responders (ODI Score ≥10)	47/67 (70.1%)	42/67 (62.7%)
Risk difference (%) and 95% CI	7.5 (−8.5 to 23.4), p=0.465
HRQoL responders (EQ-5D-5L Index Score ≥0.074)	46/67 (68.7%)	41/67 (61.2%)
Risk difference (%) and 95% CI	7.5 (−8.6 to 23.6), p=0.469
Sleep responders (PSQI Global Score≥3)	39/66 (59.1%)	27/64 (42.2%)
Risk difference (%) and 95% CI	16.9 (−0.0 to 33.8), p=0.079
Emotional function responders (POMS TMD Score≥10)	31/44 (70.5%)	18/38 (47.4%)
Risk difference (%) and 95% CI	23.1 (2.3 to 43.9), p=0.043
Multimodal treatment responders (MCID in at least two impaired domains out of VAS≥30%, ODI≥10, EQ-5D≥0.074, PSQI≥3, POMS≥10)
Responders in ≥1 impaired domain	63/67 (94.0%)	57/67 (85.1%)
Responders in ≥2 impaired domains	52/67 (77.6%)	46/67 (68.7%)
Responders in ≥3 impaired domains	47/67 (70.1%)	41/67 (61.2%)
Responders in ≥4 impaired domains	35/66 (53.0%)	26/66 (39.4%)
Responders in 5 impaired domains	21/44 (47.7%)	7/36 (19.4%)
Holistic treatment responder	30/67 (44.8%)	19/67 (28.4%)
Risk difference (%) and 95% CI	16.4 (0.3 to 32.5), p=0.072

HRQoL, health-related quality of life; MCID, minimal clinically important difference; ODI, Oswestry Disability Index; POMS, Profile of Mood States; PSQI, Pittsburgh Sleep Quality Index; SCS, spinal cord stimulation; TMD, total mood disorder; VAS, Visual Analog Scale.