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. 2024 Mar 25;73(6):1015–1024. doi: 10.1136/gutjnl-2023-330584

Figure 1.

Figure 1

Biomarkers, endpoints and other tools biomarker classification proposed by the Food and Drug Administration.11 We included some examples adapted to ACLF to demonstrate how each biomarker clarifies and describes their hierarchical relationships, connections and dependencies. ACLF, acute-on-chronic liver failure; AD, acute decompensation; AKI, acute kidney injury; CLIF, chronic liver failure; HRS, hepatorenal syndrome; NGAL, neutrophil gelatinase-associated lipocalin; PREDICT, predicting acute-on-chronic liver failure in cirrhosis.