Figure 2.
Strategies for lung and spleen-targeted LNPs delivery
(A) Double-coated GALA-MEND for pDNA delivery to lung endothelium.
(B) In vivo imaging of mice injected with MENDs (without GALA) or optimized GALA-MENDs (double-coated).
(C) Schematic representation of the transition from LNP to LNP-SNA.
(D) Spleen-specific mRNA expression comparison between LNP and LNP-SNA. (A and B) Adapted from permission.54 Copyright 2021, American Chemical Society.
(C and D) Adapted from permission.57 Copyright 2021, American Chemical Society.