Table 3.
PSMA-RGS in PCa patients.
| Year | Country | Retro/pros | Patient number | Patient type | Preoperative staging | Gamma probe | Agents for PSMA-RGS | Age | tPSA (ng/ml) | GS | sensitivity | specificity | PPV | NPV | Accuracy |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 201513 | Germany | R | 5 | Primary PCa; Recurrent PCa | 68Ga-PSMA-11 PET/CT | Crystal Probe CXS-SG603 | 111In-PSMA-I&T | 75 (IQR 64-75) | 2.45 (IQR 0.46-4.36). | —— | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% |
| 201637 | Germany | R | 31 | Recurrent Pca | 68Ga-PSMA-11 PET/CT | Crystal Probe CXS-SG603 | 111In-PSMA-I&T | 68.2 (Range 52-76) | 1.3 (IQR 0.57-2.53) | 7 (≤6-10) | 92.3% | 93.5% | 88.9% | 95.6% | 93.1% |
| 201838 | Germany | R | 6 | Primary Pca | 68Ga-PSMA-11 PET/CT | Ex situ gamma probe | 111In-PSMA-617 | 71 (IQR 66.5-75.5) | 7.03 (IQR 1.31-12.02) | 7 (7-9) | 92.1% | 98.9% | 94.6% | 98.4% | 97.7% |
| 201845 | Germany | R | 31 | Recurrent PCa | 68Ga-PSMA-11 PET/CT | Crystal Probe CXS-SG603 | 99mTc-PSMA-I&S | 66.7(IQR 60.5-73.5) | 1.13 (IQR: 0.71-2.35) | 7 (5-9) | 83.6% | 100.0% | 100.0% | 89.2% | 93.0% |
| 202149 | Germany | R | 6 | Primary PCa; Recurrent PCa | 68Ga-PSMA-11 PET/CT; 18F-PSMA-1007 | In situ/Ex situ gamma probe | 99mTc-PSMA-I&S | 64(IQR 54.7-67.3) | 33.3 (IQR: 4.6-64.4) | 8 (7b-9) | 76.6% | 94.4% | 89.4% | 86.9% | —— |
| 202242 | Netherlands | P | 20 | Recurrent Pca | 68Ga-PSMA-11; 18F-DCFPyl PET/CT | DROP-IN Gamma Probe | 99mTc-PSMA-I&S | 68 (IQR 66-72) | 1.02 (IQR 0.46-2.43). | —— | 86.0% | 100.0% | 100.0% | 95.0% | 80.0% |
| 202250 | Italy | P | 12 | Primary PCa | 68Ga-PSMA-11 PET/MRI | DROP-IN Gamma Probe | 99mTc-PSMA-I&S | 70 (IQR 66-71) | 8.7 (IQR: 4.8-15.5) | 8 (7a-9) | 63.0% | 99.0% | 83.0% | 96.0% | —— |
| 202251 | Australia | P | 12 | Primary PCa | 68Ga-PSMA-11 PET/CT | DROP-IN gamma probe | 99mTc-PSMA-I&S | 68 (IQR 57-69) | 9.15 (IQR: 6.0 - 21.2) | 9 (8-9) | 76.0% | 69.0% | 50.0% | 88%, | —— |
| 202254 | Germany | R | 364 | Recurrent Pca | PSMA PET/CT | Crystal Probe CXS-SG603 | 111In-PSMA-I&T or 99mTc-PSMA-I&S | 67 (IQR 62-71) | 1.0 (IQR: 0.5 - 1.9) | 7a (6-≥9) | —— | —— | —— | —— | —— |
| 202342 | Germany | P | 85 | Recurrent Pca | PSMA PET/CT | Crystal Probe CXS-SG603 | 99mTc-PSMA-I&S | 63 (IQR 60-69) Open; 64 (IQR60-67) Robot | 0.58 (0.38, 0.87) Open; 0.44 (0.31, 0.71) Robot | —— | —— | —— | —— | —— | —— |
| 202369 | Germany | P | 6 | Recurrent Pca | 68Ga-PSMA I&T PET/CT | Crystal Probe CXS-SG603 | 67Ga-PSMA I&T | 69.5 (IQR 63-73) | 2.7 (IQR: 1.125 - 3) | 7a (6-9) | —— | —— | —— | ——% | —— |
| 202436 | Netherlands | p | 20 | Primary PCa | 18F-PSMA PET/CT | DROP-IN gamma probe | 111In-PSMA-I&T | 69 (Range 57-79) | 22.2 (2.9-117) | —— | 66.7% | 99.8% | 96.8% | 97.0% | —— |