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. 2024 Apr 22;14(7):2719–2735. doi: 10.7150/thno.92350

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B. breve lw01 alters the transcriptional signature and the inflammatory response of colonic macrophages. (A) Scatter plot showing DEGs of the total colonic LP macrophages in the B. breve group vs PBS group in CAC mice (Red dots represent upregulated DEGs, and cyan dots represent downregulated DEGs). (B) Heatmap showing DEGs related to inflammatory response, chemotaxis, and differentiation of colonic macrophages. (C) KEGG pathway enrichment analysis of upregulated DEGs (Dot size represents the number of DEGs, and dot color represents the corresponding Q value). (D) GO pathway enrichment analysis (molecular function and biological process) of downregulated DEGs (Dot size represents the number of DEGs, and dot color represents the corresponding Q value). B. breve: Bifidobacterium breve; CAC: colitis-associated colorectal cancer; DEG: differentially expressed gene; GO-BP: biological process of Gene Ontology; GO-MF: molecular function of Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; LP: lamina propria.